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RIBOSOMAL PROTEIN S6 KINASES
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DeCS
Descriptor
English
:
Ribosomal Protein S6 Kinases
Descriptor
Spanish
:
Proteínas Quinasas S6 Ribosómicas
Descriptor
Portuguese
:
Proteínas Quinases S6 Ribossômicas
Synonyms
English
:
S6 Kinase
Tree Number:
D08.811.913.696.620.682.700.862
D12.644.360.600
D12.776.476.600
Definition
English
:
A
family
of protein serine/threonine kinases which act as intracellular signalling intermediates.
Ribosomal protein S6 kinases
are activated through
phosphorylation
in response to a variety of
HORMONES
and
INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS
.
Phosphorylation
of
RIBOSOMAL PROTEIN S6
by
enzymes
in this class results in increased expression of 5' TOP MRNAS. Although specific for
RIBOSOMAL PROTEIN S6
members of this class of kinases can act on a number of
substrates
within the cell. The immunosuppressant
SIROLIMUS
inhibits the activation of
ribosomal protein S6 kinases.
See Related
English
:
Ribosomal Protein S6
History Note
English
:
2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
33474
Unique Identifier:
D019893
Occurrence in VHL
:
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